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A massive fire ripped through a 24-storey apartment block in west London in the early hours of Wednesday, trapping residents inside as 200 firefighters battled the blaze.
An unconfirmed number of fatalities have been reported.
Witnesses could hear screaming from the upper floors as the flames rose and one desperate resident could be seen waving a white cloth.
Police and fire services attempted to evacuate the concrete block and said "a number of people are being treated for a range of injuries", including at least two for smoke inhalation.
Frantic families at the scene attempted to call their loved ones stuck inside and were being directed by police to a nearby restaurant where some of the injured were being treated.
The fire brigade said 40 fire engines and 200 firefighters had been called to the blaze in Grenfell Tower, which has 120 flats.
The ambulance service said it had sent more than 20 ambulance crews to the scene.
"Fire is from 2nd to top floor of 27 storey building," the fire service said on Twitter.
